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CAS No.: 69049-74-7

Synonyms: FPL 59002KP;Nedocromil disodium salt;Nedocromil (sodium salt)

Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述Nedocromil sodium is a mast cell stabilizer that inhibits the release of mediators from mast cells. It inhibited the enhancing effects of interleukin 2 (IL-2) on compound 48/80 and anti-IgE antibody-mediated mast cell activation at a dose of 10^-5M when added with mast cell activators or during the pre-incubation period. Nedocromil sodium also completely abolished IL-2-induced spontaneous histamine release from mast cells. In the co-culture of rat peritoneal mast cells and 3T3 fibroblasts, nedocromil sodium decreased basal histamine release from mast cells by 23%.^[1] In both active and passive rat models of conjunctival immediate hypersensitivity, administration of nedocromil sodium at a dosage of 2mg/kg significantly inhibited emergence of conjunctival edema and erythema and reduced mast cell degranulation.^[2]
作用机制Nedocromil sodium is a mast cell stabilizer of proven efficacy in treating asthma.^[2]
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技术信息

CAS号	69049-74-7	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C19H15NNa2O7	运输	蓝冰
分子量	415.30	别名	FPL 59002KP;Nedocromil disodium salt;Nedocromil (sodium salt);Alocril;Tilade

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